Manuka is popular because it has strong antibacterial properties. Medicinal Manuka Honey Uses These are situations where the antibacterial aspects of the honey are significant. As a result, higher levels of antibacterial activity are going to be more powerful. Some such uses include the following: For fighting a cold or an infection Applied to the skin to promote wound or burn healing For improving digestion or colon health As a cough or sore throat remedy For treating acne, hives and eczema