A major benefit of this cream is that it has been specially formulated to provide maximal effectiveness. In this regard, it has the exact strength needed to block the toxic effects of estrogen, insulin, and adrenaline. PlattPro has a 5% strength, which means that one pump provides 50 mg of progesterone. After it is applied, progesterone only lasts for about 5-6 minutes in the bloodstream because it is quickly picked up by receptor sites. Since it is so short acting, the best time to use progesterone is 1-3 minutes before eating. The most important time of day to use progesterone is before lunch. Insulin levels are the highest in the afternoon, which, of course, is why many people get sleepy between 3-4PM. Please keep in mind that when sugar levels drop, the body will be releasing adrenaline to raise the sugar levels back up. Recommended Dose; Strength: 50 mg per pump Apply ½-1 pump to inside of one forearm and rub forearms together Do this up to 3 times a day, 1-3 minutes before meals If you have trouble sleeping at night, it is recommended that you eat a low-glycemic carbohydrate just before going to bed. In addition, apply the cream again just before eating your bedtime snack. For more more information, pleaset visit plattwellness.com and click on the Benefits of Progesterone. For questions regarding this product you can contact Dr. Platt directly at [email protected]. Free hormone evaluations are also offered on our Shop tab.